Keratinocyte Gene Transfer and Gene Therapy

Gene Transfer and Gene Therapy

however, suffer from a problem implied by its title. Dr. Schull's attempts to make the book lyrical lead to the sin of vivid writing, often complicated by inappropriate usages. For example, it seems unlikely that the lanes mentioned on page 15 were "tortured"; "tortuous" is more likely. Can sleep come in "dollops" (page 22)? Do physicians actually ride jeeps like "marauding bees" (page 26)? (Ar...

Anticancer gene transfer for cancer gene therapy.

Gene therapy vectors are among the treatments currently used to treat malignant tumors. Gene therapy vectors use a specific therapeutic transgene that causes death in cancer cells. In early attempts at gene therapy, therapeutic transgenes were driven by non-specific vectors which induced toxicity to normal cells in addition to the cancer cells. Recently, novel cancer specific viral vectors have...

Adeno-associated viral vectors for gene transfer and gene therapy.

Adeno-associated virus (AAV) is a defective, non-pathogenic human parvovirus that depends for growth on coinfection with a helper adenovirus or herpes virus. Recombinant adeno-associated viruses (rAAVs) have attracted considerable interest as vectors for gene therapy. In contrast to other gene delivery systems, rAAVs lack all viral genes and show long-term gene expression in vivo without immune...

ژن درمانی Gene Therapy

Adenoviral vector-mediated gene transfer for human gene therapy.

Human gene therapy promises to change the practice of medicine by treating the causes of disease rather than the symptoms. Since the first clinical trial made its debut ten years ago, there are over 400 approved protocols in the United States alone, most of which have failed to show convincing data of clinical efficacy. This setback is largely due to the lack of efficient and adequate gene tran...